While I'm a big fan of Elizabeth Warren, I don't think she's managed to accomplish much in the Senate. Now that's fine, no one in the Senate has accomplished much and she has managed to raise a lot of money (though I wish there was less money in politics). I've been mostly annoyed with all the questions about should she run for President. To me the obvious answer is no. But Ezra Klein gives 6 reasons Elizabeth Warren should run for president and I find them pretty compelling.
Most of it comes down to that by doing so she could have more influence in political agenda and if she loses she'll probably have more influence as a prominent Senator. And hey, Obama won with not much more experience.